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They were also observed associated with epithelial structures in lung and kidney, but were only rarely observed in liver, thyroid, testis and spleen. [en] Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets of mesenchymal cells, cancer-associated macrophages and antigen-presenting cells. Our results revealed that the dermis of patch- and plaque-stage KS lesions contains an increased number of factor XIIIa-positive dermal dendrocytes compared with normal dermis and that some of these cells are spindle shaped. Many of the spindle cells in patch- and plaque-stage lesions of KS, however, are negative for factor XIIIa. Comparison of Angiomyofibroblastoma and Aggressive Angiomyxoma in Both Sexes: Four Cases Composed of Bimodal CD34 and Factor XIIIa Positive Dendritic Cell Subsets Author links open overlay panel Jeffrey S. Silverman 1 2 Jak Albukerk 1 2 Ali Tamsen 1 2 Factor XIIIA is the catalytic subunit and is a dimer of M.W. 160,000. According to studies, Factor XIII is present in plasma as an alpha2beta2 heterodimer (M.W.

Silverman and A. Tamsen}, … Anti- Factor XIIIa has been found to be useful in differentiating between dermatofibroma (90% positive) and desmoplastic malignant melanoma (negative). Factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor , and meningioma. Title : Factor Xiiia-Positive Dendrocytes and Proliferative Activity of Cutaneous Cancers: Language : English: Author, co-author : Pierard-Franchimont, Claudine [Université de Liège - ULiège > > Dermatopathologie >]: Arrese Estrada, Jorge [Université de Liège - ULiège > > Dermatopathologie >]: Nikkels, Arjen [Université de Liège - ULiège > > Dermatologie >] Before you can use immunostains to help recognize different tumors and diseases in dermpath, you must first understand how they stain the normal structures i Our results revealed that the dermis of patch- and plaque-stage KS lesions contains an increased number of factor XIIIa-positive dermal dendrocytes compared with normal dermis and that some of these cells are spindle shaped. Many of the spindle cells in patch- and plaque-stage lesions of KS, however, are negative for factor XIIIa.

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

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Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII.

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They are subsets of mesenchymal cells, cancer-associated macrophages Add photo 1 Synonyms 2 Antibodies 3 Technical Info 4 Staining Pattern 5 Expression in Normal Tissues 6 Expression in Neoplastic Entities 6.1 Benign 6.2 Benign 6.3 Intermediate/Uncertain Malignant Potential 6.4 Malignant 7 Expression in Non-Neoplastic Entities 8 Practical Uses / Panels 9 Common Pitfalls 10 References Cytoplasmic Histiocytes Fibrohistiocytes Factor XIIIa can be used in a panel Supporting: 1, Mentioning: 23 - Immunohistochemical staining for factor XIIIa, a transglutaminase, revealed a variety of positively stained cells in human fetal tissues.

Factor XIIIa is a blood coagulation prototransglutaminase 1, which becomes an activated component of the final stages of the clotting cascade as a result of the interaction with thrombin and Ca 2+. Immunohistochemical analysis showed that factor XIIIa-positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Factor XIIIa-positive dermal dendritic cells and HLA-DR expression in radial versus vertical growth-phase melanomas. Fullen DR(1), Headington JT. Author information: (1)Department of Pathology, University of Michigan Hospitals, Ann Arbor, USA. Comment in J Cutan Pathol. 1999 May;26(5):263-4.
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Deficiency of XIII worsens clot stability and increases bleeding tendency. Human XIII is a heterotetramer. Staining pattern is highly variable and nonspecific but the following stains may be positive: Factor XIIIa, CD163, CD10. Factor XIIIa is usually negative in DFSP. CD68 may highlight histiocytic cells (Patterson: Weedon's Skin Pathology, 5th Edition, 2020) FXIIIa positive cells in human skin represent a specific population of bone-marrow dermal dendritic cells, distinct from Langerhans cells, that share some features common to mononuc-lear phagocytes (monocyte/macrophages).

Numerous large, stellate cells in placental villi, decidua, and chorionic membranes also expressed factor XIIIa at 7–9 weeks gestational age, before the onset of fetal hematopoiesis. The immunocytochemical identification and characterization of indigenous dermal dendritic cells (dermal dendrocytes) using a rabbit polyclonal antibody to clotting enzyme factor XIII subunit A (FXIIIa) was carried out on normal and inflamed human cutaneous tissue. Factor XIIIa-positive dendrocytes were plentiful in the uninvolved dermis and were aggregated around the periphery of the tumor nodules. Factor XIIIa is more likely to be negative Tuberous xanthoma: Occurs in areas of pressure Associated with hypercholesterolemia and high LDL Consists of dermal aggregates of foam cells, no Touton cells or inflammatory cells Spitz nevus: Nests of spindle and epithelioid cells within a uniformly hyperplastic epidermis DFSP is diffusely CD34 positive and Factor XIIIa negative, whereas dermatofibromas (and additional fibrohistiocytic tumor types other than DFSP) show the converse of this profile or only limited CD34 reactivity at the advancing edge of the lesion.
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Newcomer Supply Factor XIIIa (fibrin stabilizing factor) Control Slides are for the positive immunohistochemical staining of Factor XIIIa, a blood coagulation Factor XIII or fibrin stabilizing factor is a zymogen found from the blood of humans and some other animals. It is activated by thrombin to factor XIIIa. XIIIa is an BALB/C mice were injected with recombinant human protein corresponding to A- subunit of coagulation Factor XIII. Positive control.

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The numbers of FXIIIa-positive cells were counted in the keloid, hypertrophic scar and mature scar, each of which was divided into fibrocollagenous area and superficial dermal area overlying the nodular lesion. Factor XIIIa positive cells in human skin represent a specific population of bone marrow dermal dendritic cells, distinct from Langerhans cells which share some features common to mononuclear phagocytes. Dendritic, factor XIIIa positive cells were observed in all tissues studied, but were most numerous in skin and mucosal tissues (gastrointestinal tract, bladder). They were also observed associated with epithelial structures in lung and kidney, but were only rarely observed in liver, thyroid, testis and spleen. Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot.